Manchester City marched into the FA Cup fifth round after a hat-trick from Kelechi Iheanacho helped them to a 4-0 win over Aston Villa.
The striker’s treble saw Manuel Pellegrini’s men cruise in the fifth round just days after they reached the League Cup final.
City also remain in the hunt to regain their Barclays Premier League crown and face Dynamo Kiev in the Champions League next month.
The impressive Iheanacho added to his early strike with a cool penalty before running through unchallenged in the second half to claim the match ball.
Raheem Sterling hooked in a fourth at Villa Park to ensure Sergio Aguero and David Silva were never needed from the bench.
But in 19-year-old Iheanacho, who now has eight goals this season, they have a striker who demonstrated he can be an able deputy to Aguero after he ran Villa ragged.
Alexis Sanchez scored on his first start since November as Arsenal defeated Burnley 2-1 in the FA Cup at The Emirates.
Sanchez, who had been sidelined for more than two months with a hamstring injury, laid on Calum Chambers for the opening goal of the game.
Sam Vokes then stunned The Emirates when he hauled Burnley level with a header after 30 minutes, but Sanchez completed a fine move shortly after the interval to seal the win.
Arsene Wenger vowed to field an experienced side for the fourth-round tie, but the Frenchman made nine changes to the team which started the 1-0 defeat against Chelsea last Sunday.
Olivier Giroud and Laurent Koscielny were the only survivors as Mohamed Elneny made his debut while Francis Coquelin was also back in Wenger’s side following a two-month injury lay-off.
Tottenham cruised into the fifth round of the FA Cup on Saturday after their first ever meeting with Colchester resulted in a 4-1 win.
Chadli, making his 100th appearance for the club, has now scored four goals in three games, while Eric Dier and Tom Carroll were also on target as Spurs won a fourth straight game.
Ben Davies’ own goal was a mere consolation for League One’s bottom club, whose chances were dealt a significant blow after a sickening clash of heads in the second minute.
Alex Wynter was treated by both medical teams before he was carried off on a stretcher and taken to hospital after colliding with team-mate Tom Eastman.
He had lost consciousness, but Colchester later reported he was sitting up in hospital, under observation.
Liverpool were held to a goalless draw at home to West Ham in the FA Cup fourth round, adding yet another fixture to their packed schedule.
A replay in east London next month was probably the last thing manager Jurgen Klopp wanted, having just completed a run of nine matches in 29 days in January.
Odion Ighalo came off the bench to net his 15th goal of the season with an 89th-minute strike that gave Watford a 1-0 win at Nottingham Forest in the FA Cup.
The hosts had looked set to extend their unbeaten run to 14 games in all competitions in a contest where two much-changed sides mustered little at the City Ground.
Wilfried Zaha inspired Crystal Palace to a 1-0 win over Stoke as they progressed to the fifth round of the FA Cup.
The talented winger built on his improving form and growing confidence with a fine individual goal that was enough to secure victory against such uninspired opposition.
Peterborough twice fought back from a goal down to earn a replay with West Brom as it finished 2-2 after a thrilling finale in the FA Cup at The Hawthorns.
It looked like Saido Berahino’s early strike would be all that separated the sides but three goals in eight frantic minutes mean the League One promotion hopefuls will get another chance at the ABAX Stadium next month.
Shaquile Coulthirst equalised after 79 minutes but Berahino quickly restored West Brom’s lead before substitute Jon Taylor levelled things up again with four minutes remaining.
Joshua King and Marc Pugh saved Bournemouth’s blushes in scrambling a 2-1 FA Cup fourth-round victory at League Two side Portsmouth.
Boss Eddie Howe got away with making 10 changes from the 1-1 Premier League draw at Sunderland – but only just.
Gary Roberts’ strike put a dominant Portsmouth into a deserved 1-0 half-time lead, only for Howe’s re-jig on the hour to turn the tie on its head.
Howe sacrificed the ineffectual Glenn Murray and the inconsistent Juan Iturbe, and pushed King through the middle in a switch that sent Bournemouth into the fifth round for the first time since 1989.
The men from the bottom tier of the Football League – FA Cup winners during their Premier League days in 2008 – spent the first half dominating their top-flight foes. At that point they were moving the ball – and Bournemouth – around with ease.
The Championship will still be well represented in the fifth round with Leeds, Blackburn, Hull and Reading all going through.
Sheffield Wednesday lost 3-2 at League Two side Shrewsbury.
The Shrews stunned their higher-ranked opponents with defender Jack Grimmer’s stoppage time header clinching a 3-2 win over the Owls.
Lewis McGugan had twice put the Championship side ahead but Jean-Louis Akpa Akpro and Shaun Whalley, following up Akpa Akpro’s saved penalty, levelled before Grimmer sent the League One side through to the last 16.
On-loan striker Chuba Akpom scored his first senior hat-trick as Championship leaders Hull eased through 3-1 at Bury.
Akpom opened the scoring after 14 minutes and converted his second from the penalty spot close to the hour-mark after Sone Aluko had been tripped.
The Arsenal man completed his treble after 69 minutes for the 2014 finalists, with Craig Jones finding the net late on for the League One Shakers.
Blackburn coasted home 3-0 at League Two Oxford with Ben Marshall scoring twice, one from the penalty spot, and Tony Watt adding another on his debut following his loan move from Charlton.
Oxford had beaten Premier League Swansea in the third round but were 2-0 down by half-time and never looked like producing another upset.
Reading reached the semi-finals last season and might be eyeing another cup run after thrashing League One Walsall 4-0.
Matej Vydra scored twice after Hal Robson-Kanu had opened the scoring and Danny Williams was also on the scoresheet.
Leeds won with Souleymane Doukara and new signing Toumani Diagouraga scoring first-half goals at Bolton, with Darren Pratley managing a late reply for the hosts.
On Friday evening, Manchester United secured a comfortable 3-1 win at the iPro thanks to goals from Wayne Rooney, Daley Blind, and Juan Mata to become the first team into the hat for the fifth round draw.
George Thorne’s equaliser before half-time might have had Van Gaal worrying again as Derby threatened to add their name to the list of lower league teams, which include MK Dons, Cambridge, Middlesbrough and Sheffield United, to cause United problems in the cups under his tenure.
Colchester United 1 – 4 Tottenham Hotspur
Arsenal 2 – 1 Burnley
Aston Villa 0 – 4 Manchester City
Bolton Wanderers 1 – 2 Leeds United
Bury 1 – 3 Hull City
Crystal Palace 1 – 0 Stoke City
Nottingham Forest 0 – 1 Watford
Oxford United 0 – 3 Blackburn Rovers
Portsmouth 1 – 2 AFC Bournemouth
Reading 4 – 0 Walsall
Shrewsbury Town 3 – 2 Sheffield Wednesday
West Bromwich Albion 2 – 2 Peterborough United
Liverpool 0 – 0 West Ham United
Derby 1 – 3 Manchester United